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ritlecitinib will enhance the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Ritlecitinib inhibits CYP3A4 substrates; coadministration raises AUC and peak plasma concentration sensitive substrates, which can enhance risk of adverse reactions.Keep track of Intently (2)ef